The role of capsule stiffness on cellular processing

H Sun; EHH Wong; Y Yan; J Cui; Q Dai; J Guo; GG Qiao; F Caruso

Journal article

The role of capsule stiffness on cellular processing

H Sun, EHH Wong, Y Yan, J Cui, Q Dai, J Guo, GG Qiao, F Caruso

Chemical Science | Published : 2015

DOI: 10.1039/c5sc00416k

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Abstract

Particle stiffness is emerging as an important parameter in determining the cell uptake dynamics of particles. Understanding the effects of capsule stiffness on their biological behavior is essential for the development of polymer capsules as therapeutic carriers. Herein, we report the preparation of polysaccharide capsules via atom transfer radical polymerization-mediated continuous assembly of polymers (CAPATRP) on silica templates using methacrylated hyaluronic acid (HA) as the macrocrosslinker. This approach affords HA capsules with controllable wall thickness and tunable stiffness. The influence of capsule stiffness on cellular interaction and intracellular distribution is systematicall..

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University of Melbourne Researchers

Greg Qiao Author

Frank Caruso Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This research was funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (CE140100036), the Australian Research Council under the Australian Laureate Fellowship (FL120100030, F.C.), Future Fellowship (FT110100411, G.G.Q.), Discovery Project (DP1094147 and DP130101846, F.C., G.G.Q.), Super Science Fellowship (FS110200025, F.C. and G.G.Q.), and Discovery Early Career Researcher Award (Y.Y., DE130100488) schemes. We acknowledge Martin P. van Koeverden for providing the P(METAOTs-co-BIEM) macroinitiator.